ONGENTYS is the first and only once-daily treatment that can optimize levodopa therapy for people experiencing PD "off" time

With Parkinson's disease, it may feel like your current treatment isn't doing enough

Parkinson's disease is a progressive neurological disorder that affects movement.

Clock icon
If you're taking CD/LD to manage your Parkinson's disease symptoms, you may experience "off" time.
Shaking hands icon
"Off" time is when your symptoms, such as stiffness or tremors, return between regular doses of medication. "Off" time can happen when your CD/LD is wearing off.

However, there is a way to reduce these "off" time periods.


Not all of the levodopa you take makes it to the brain

In Parkinson's disease, there are two major enzymes that break down levodopa, DDC=DOPA decarboxylase. and COMT=catechol-O-methyltransferase.. Carbidopa can block DDC from breaking down levodopa.

But this leaves COMT to continue breaking down levodopa before it reaches the brain.

Choose to optimize your CD/LD by adding a once-daily capsule, taken at bedtime

Capsule icon
Introducing ONGENTYS—the first and only once-daily treatment that blocks the peripheral COMT enzyme to help optimize your levodopa.
Brain icon
By blocking the COMT enzyme from breaking down levodopa, ONGENTYS helps to reduce "off" time by keeping levodopa levels steady for longer.
'Off' time clock icon

ONGENTYS can help reduce your daily "off" time

In clinical studies, adding ONGENTYS once daily at bedtime reduced daily "off" time by an average of about 2 hours per day compared to about 1 hour for people taking CD/LD without ONGENTYS.

Calendar icon

Minimal changes to CD/LD dosing over 1 year

Not only did ONGENTYS reduce daily "off" time during the first 14–15 weeks of clinical studies, but the majority of people taking ONGENTYS had no changes to their CD/LD dosing through 1 year.

ONGENTYS is taken at bedtime. Do not eat 1 hour before or after taking ONGENTYS because food can impact how well it works.

Understanding side effects

Before starting ONGENTYS, talk to your doctor about all of your medical conditions, as well as the potential side effects ONGENTYS may cause when starting treatment.

The most common side effects of ONGENTYS are:

  • Uncontrolled sudden movements (dyskinesia)
  • Constipation
  • Increase in a certain enzyme called blood creatine kinase
  • Low blood pressure
  • Weight loss

ONGENTYS may cause serious side effects, including:

  • Falling asleep during normal activities without being drowsy or without warning
  • Low blood pressure or dizziness, lightheadedness, or fainting
  • Uncontrolled sudden movements (dyskinesia)
  • Seeing, hearing, or feeling things that are not real (hallucinations), believing things that are not real (delusions), or aggressive behavior
  • Unusual urges (impulse control and compulsive disorders) and the inability to control these urges
Call HCP for assistance icon
These are not all of the possible side effects of ONGENTYS. Click here for important safety information. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1‑800‑FDA‑1088.
Choose a treatment that doesn't interfere with your daily routine