Choose to enhance your levodopa/carbidopa
with a simple once-daily capsule
In Parkinson's disease, there are 2 major enzymes that break down levodopa, DDC=dopa decarboxylase. and COMT=catechol-O-methyltransferase. .
Because levodopa is paired with carbidopa, a DDC inhibitor, the DDC enzyme is blocked.
However, COMT may still be breaking down some of your levodopa before it reaches the brain.
Introducing ONGENTYS—the first and only once-daily treatment that blocks the COMT enzyme to help enhance your levodopa
By blocking the COMT enzyme from breaking down levodopa, ONGENTYS allows for more of the levodopa you're already taking to be available to reach the brain
Choose a once-daily levodopa/carbidopa enhancer:
ONGENTYS can help reduce your daily OFF time is when your symptoms—such as stiffness or tremors—return between regular doses of medication. OFF time can happen when your levodopa/carbidopa is wearing off.
In clinical studies, adding ONGENTYS reduced daily OFF time by an average of about 2 hours per day compared to about 1 hour for people taking levodopa/carbidopa without ONGENTYS.
ONGENTYS can help reduce your daily OFF time is when your symptoms—such as stiffness or tremors—return between regular doses of medication. OFF time can happen when your levodopa/carbidopa is wearing off.
In clinical studies, adding ONGENTYS reduced daily OFF time by an average of about 2 hours per day compared to about 1 hour for people taking levodopa/carbidopa without ONGENTYS.
Minimal changes to levodopa/carbidopa dosing over 1 year
Not only did ONGENTYS reduce daily OFF time during the first 14-15 weeks of clinical studies, but the majority of people taking ONGENTYS had no changes to their levodopa/carbidopa dosing through 1 year.
Minimal changes to levodopa/carbidopa dosing over 1 year
Not only did ONGENTYS reduce daily OFF time during the first 14-15 weeks of clinical studies, but the majority of people taking ONGENTYS had no changes to their levodopa/carbidopa dosing through 1 year.
Talk to your doctor to see if once-daily ONGENTYS can reduce your daily OFF time
Understanding side effects
Before starting ONGENTYS, talk to your doctor about all of your medical conditions, as well as the potential side effects ONGENTYS may cause.
The most common side effects are:
- Uncontrolled sudden movements (dyskinesia)
- Constipation
- Increase in a certain enzyme called blood creatine kinase
- Low blood pressure
- Weight loss
ONGENTYS may cause serious side effects, including:
- Falling asleep during normal activities without being drowsy or without warning
- Low blood pressure or dizziness, light headedness, or fainting
- Uncontrolled sudden movements (dyskinesia)
- Seeing, hearing, or feeling things that are not real (hallucinations), believing things that are not real (delusions), or aggressive behavior
- Unusual urges (impulse control and compulsive disorders) and the inability to control these urges
These are not all of the possible side effects of ONGENTYS. For a full list of side effects, please click here. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
These are not all of the possible side effects of ONGENTYS. For a full list of side effects, please click here. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Choose a treatment that doesn't interfere with your daily routine
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