Doctor Discussion Guide
Use this Doctor Discussion Guide to help start a conversation with your doctor about adding once-daily ONGENTYS to enhance your levodopa/carbidopa treatment and reduce OFF time is when your symptoms—such as stiffness or tremors—return between regular doses of medication. OFF time can happen when your levodopa/carbidopa is wearing off.
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Frequently Asked Questions
Remember to talk to your doctor about any questions you may have about ONGENTYS
ONGENTYS is a prescription medicine used with levodopa and carbidopa in people with Parkinson’s disease (PD) who are having “OFF” episodes. It is not known if ONGENTYS is safe and effective in children.
Do not take ONGENTYS if you:
- take a type of medicine called a non-selective monoamine-oxidase (MAO) inhibitor, such as phenelzine, isocarboxazid, or tranylcypromine. Ask your healthcare provider or pharmacist if you are taking a non-selective MAO inhibitor.
- have a tumor that secretes hormones known as catecholamines. These tumors include pheochromocytoma (a type of adrenal gland tumor) and paraganglioma.
In Parkinson's disease, there are 2 major enzymes that break down levodopa, DDC=dopa decarboxylase. and COMT=catechol-O-methyltransferase. .
Because levodopa is paired with carbidopa, a DDC inhibitor, the DDC enzyme is blocked. However, COMT may still be breaking down some of your levodopa before it reaches the brain.
By blocking the COMT enzyme from breaking down levodopa, once-daily ONGENTYS allows for more of the levodopa you're already taking to be available to reach the brain.
Before taking ONGENTYS, tell your healthcare provider about all of your medical conditions, including if you:
- have daytime sleepiness from a sleep disorder, have unexpected or unpredictable periods of sleep or sleepiness, take a medicine to help you sleep, or take any medicine that makes you feel sleepy
- have or have had intense urges or unusual behaviors, including gambling, increased sex drive, binge eating, or compulsive shopping
- have a history of uncontrolled sudden movements (dyskinesia)
- have or have had hallucinations or psychosis
- have liver problems
- have kidney problems
- are pregnant or plan to become pregnant. It is not known if ONGENTYS will harm your unborn baby
- are breastfeeding or plan to breastfeed. It is not known if ONGENTYS passes into breast milk. You and your healthcare provider should decide the best way to feed your baby if you take ONGENTYS
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take nonselective MAO inhibitors (such as phenelzine, tranylcypromine, and isocarboxazid) or catecholamine medicines (such as isoproterenol, epinephrine, norepinephrine, dopamine, and dobutamine), regardless of how you take the medicine (by mouth, inhaled, or by injection).
ONGENTYS and other medicines may affect each other causing side effects. ONGENTYS may affect the way other medicines work, and other medicines may affect how ONGENTYS works.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
Do not drive, operate machinery, or do other dangerous activities until you know how ONGENTYS affects you.
Your individual results may vary. In clinical studies, adding ONGENTYS reduced daily OFF time is when your symptoms—such as stiffness or tremors—return between regular doses of medication. OFF time can happen when your levodopa/carbidopa is wearing off. by an average of about 2 hours compared to about 1 hour for people taking levodopa/carbidopa without ONGENTYS at 14-15 weeks.
Not only did ONGENTYS reduce daily OFF time during the first 14–15 weeks of clinical studies, but the majority of people taking ONGENTYS had no changes to their levodopa/carbidopa dosing through 1 year.
ONGENTYS may cause serious side effects, including:
- Falling asleep during normal activities such as driving a car, talking or eating while taking ONGENTYS or other medicines used to treat Parkinson’s disease, without being drowsy or without warning. This may result in having accidents. Your chances of falling asleep while taking ONGENTYS are higher if you take other medicines that cause drowsiness.
- Low blood pressure or dizziness, light headedness, or fainting.
- Uncontrolled sudden movements (dyskinesia). ONGENTYS may cause uncontrolled sudden movements or make such movements worse or happen more often.
- Seeing, hearing, or feeling things that are not real (hallucinations), believing things that are not real (delusions), or aggressive behavior.
- Unusual urges (impulse control and compulsive disorders) such as urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.
Tell your healthcare provider if you experience any of these side effects or notice changes in your behavior.
The most common side effects of ONGENTYS include uncontrolled sudden movements (dyskinesia), constipation, increase in an enzyme called blood creatine kinase, low blood pressure, and weight loss.
These are not all of the possible side effects of ONGENTYS. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Take ONGENTYS exactly as your healthcare provider tells you to. ONGENTYS should be taken 1 time each day at bedtime. Do not eat for 1 hour before taking ONGENTYS and do not eat for at least 1 hour after taking ONGENTYS.
If you miss a dose, take your usual dose of ONGENTYS on the next day at bedtime. Do not stop taking ONGENTYS or change your dose before talking to your healthcare provider.
Your dose of other Parkinson’s disease medicines may change when stopping ONGENTYS. Tell your healthcare provider if you have symptoms of withdrawal such as fever, confusion, or severe muscle stiffness.
If you take too much ONGENTYS, call your healthcare provider or Poison Control Center at 1-800-222-1222, or go to the nearest hospital emergency room right away.
ONGENTYS works with your existing levodopa/carbidopa routine. In clinical studies, the majority of people taking ONGENTYS did not have to change their levodopa/carbidopa dosing regimen through 1 year. Your individual results may vary.
If you experience dyskinesia while taking ONGENTYS, tell your doctor as he/she may need to adjust your levodopa/carbidopa dosage or other medications.
With the ONGENTYS Savings Program, you may be eligible for a $0 copay on your ONGENTYS prescription.* If you do not have prescription coverage for ONGENTYS, you may be able to receive your prescription at no cost through the ONGENTYS Patient Assistance Program.†
For more information about either of these programs, you can talk to an INBRACE® Support Program representative by calling toll-free 1-833-ONGENTYS or 1-833-664-3689, 8 AM to 8 PM (ET), Monday through Friday, or visit INBRACESupportProgram.com.
* This offer is valid only for patients who have commercial (nongovernment-funded) insurance. Additional terms and conditions apply.
† Additional terms and conditions apply.
When it comes to living with Parkinson’s disease, support is available. Below are some advocacy groups that can help you further understand Parkinson’s disease, OFF time is when your symptoms—such as stiffness or tremors—return between regular doses of medication. OFF time can happen when your levodopa/carbidopa is wearing off. , and more.
This site offers the support, education, and research that will help everyone impacted by Parkinson’s disease live life to the fullest. Find resources and a chapter in your community.
This site offers a wealth of online resources geared to help you live well today, from blog posts to manuals full of practical information every family affected by Parkinson’s should read.
Dozens of livestream and in-person programs for support group leaders, care partners, adult children and residential facilities in addition to education for the general PD and movement disorder community from physician advisors. National listing of support and exercise groups in all 50 states as well as national, regional, and local organizations are just some of the offerings you’ll find here.
The Parkinson’s Foundation makes life better for people with Parkinson’s disease by improving care and advancing research toward a cure.
This site offers resources about Parkinson’s disease, its symptoms, and medications, as well as guides for navigating life with Parkinson’s disease, how to build a care team, managing depression and anxiety, and more.